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Kossiakoff, Anthony
One or more keywords matched the following items that are connected to Kossiakoff, Anthony
Item TypeName
Concept Acetyl Coenzyme A
Concept Antigen-Antibody Complex
Concept Bacillus
Concept Cyclic AMP
Concept Antiviral Agents
Concept Calmodulin
Concept Calorimetry, Differential Scanning
Concept Antibodies, Monoclonal
Concept Base Sequence
Concept Cations, Divalent
Concept Deuterium
Concept Bacillus anthracis
Concept Bacillus subtilis
Concept Dolichol Monophosphate Mannose
Concept Camelids, New World
Concept Cattle
Concept Camelus
Concept Blood-Brain Barrier
Concept Fungi
Concept Genetic Vectors
Concept Cricetulus
Concept Ciona intestinalis
Concept Clostridium perfringens
Concept Hormones
Concept Hydrogen
Concept Cyanogen Bromide
Concept Immunoglobulin Fab Fragments
Concept Insulysin
Concept Endodeoxyribonucleases
Concept Disulfides
Concept Chaetomium
Concept Electrophoresis, Polyacrylamide Gel
Concept Freeze Drying
Concept Electrophysiology
Concept Enzyme Inhibitors
Concept Immunoglobulin Fragments
Concept Immunoglobulin Fc Fragments
Concept Chromatography, High Pressure Liquid
Concept Enzyme Activation
Concept Gene Expression Regulation
Concept Genetic Complementation Test
Concept Dolichol Phosphates
Concept Hydrogen-Ion Concentration
Concept Peroxides
Concept Enzyme-Linked Immunosorbent Assay
Concept Hepatitis B
Concept Escherichia coli
Concept Fourier Analysis
Concept Heme
Concept Membrane Glycoproteins
Concept Metalloendopeptidases
Concept Hydrolysis
Concept Phosphatidylcholines
Concept Immunoglobulin Variable Region
Concept Pancreatic Neoplasms
Concept Mice, Nude
Concept Micrococcal Nuclease
Concept Random Allocation
Concept Mutation
Concept Myoglobin
Concept Hot Temperature
Concept Nucleic Acid Conformation
Concept Ovarian Neoplasms
Concept Lipopolysaccharides
Concept Lung Neoplasms
Concept Oocytes
Concept Maltose
Concept Endopeptidases
Concept Microscopy, Electron
Concept Polyisoprenyl Phosphate Monosaccharides
Concept Streptomyces griseus
Concept Tissue Plasminogen Activator
Concept Protein Processing, Post-Translational
Concept Protease Inhibitors
Concept Glutamine
Concept Immunoglobulin G
Concept Receptors, Prolactin
Concept Rabbits
Concept Polystyrenes
Concept Trypsin Inhibitors
Concept Relaxin
Concept X-Ray Diffraction
Concept Interferon-gamma
Concept Serpins
Concept Saimiri
Concept Sensitivity and Specificity
Concept Swine
Concept Sheep
Concept Humans
Concept Genetic Variation
Concept Protein Engineering
Concept Gene Library
Concept O Antigens
Concept Antibodies, Blocking
Concept Arrestin
Concept Cryoelectron Microscopy
Concept Guanine Nucleotide Exchange Factors
Concept Cell Adhesion Molecules
Concept Fatty Acids, Omega-3
Concept Mutagenesis, Site-Directed
Concept Sequence Alignment
Concept Drug Delivery Systems
Concept Sequence Analysis, DNA
Concept Methane
Concept Neutralization Tests
Concept Amyloid beta-Protein Precursor
Concept Antibodies, Bispecific
Concept Crystallography, X-Ray
Concept Cell Proliferation
Concept GTP-Binding Protein alpha Subunits, Gs
Concept Receptors, Adrenergic, beta-2
Concept Epitopes, B-Lymphocyte
Concept GTP-Binding Protein alpha Subunits, Gi-Go
Concept Deuterium Oxide
Concept Proteomics
Concept G-Protein-Coupled Receptor Kinase 1
Concept COS Cells
Concept Amino Acid Substitution
Concept Hydroxymethylglutaryl-CoA Reductase Inhibitors
Concept ras GTPase-Activating Proteins
Concept Arrestins
Concept Plasmodium falciparum
Concept Saccharomyces cerevisiae Proteins
Concept Prolactin
Concept Mice
Concept Focal Adhesion Protein-Tyrosine Kinases
Concept Pyrans
Concept Ribonucleases
Concept Saccharomyces cerevisiae
Concept Substance P
Concept Rats
Concept Paxillin
Concept Static Electricity
Concept Antibodies, Monoclonal, Humanized
Concept Streptomyces lividans
Concept Trypsin
Concept Adaptor Proteins, Signal Transducing
Concept Temperature
Concept Serine Proteinase Inhibitors
Concept Tetrahymena
Concept Reproducibility of Results
Concept Amyloid beta-Peptides
Concept Receptor, ErbB-2
Concept Bacteriophage M13
Concept CD3 Complex
Concept GTP-Binding Proteins
Concept Sequence Analysis, Protein
Concept Carcinoma, Pancreatic Ductal
Concept Xenograft Model Antitumor Assays
Concept Peptide Library
Concept HIV Integrase
Concept Janus Kinase 2
Concept AMP-Activated Protein Kinases
Concept Escherichia coli K12
Concept Single-Chain Antibodies
Concept Antibodies, Neutralizing
Concept Alzheimer Disease
Concept Antibodies
Concept Cell Survival
Concept Chickens
Concept Chromatin
Concept Chymotrypsin
Concept Cloning, Molecular
Concept Drug Screening Assays, Antitumor
Concept Fibrinolysin
Concept Glucose
Concept Hepatitis B virus
Concept Histidine
Concept Kinetics
Concept Lymphocyte Activation
Concept Magnetic Resonance Imaging
Concept Microscopy, Fluorescence
Concept Recombinant Fusion Proteins
Concept Serine Endopeptidases
Concept Subtilisins
Concept T-Lymphocytes
Concept HIV-1
Concept Cytokines
Concept Helix-Turn-Helix Motifs
Concept Point-of-Care Systems
Concept Computational Biology
Concept Complementarity Determining Regions
Concept Ebolavirus
Concept Ubiquitination
Academic Article Structural consequences of mutation.
Academic Article Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor.
Academic Article Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Academic Article Analysis of solvent structure in proteins using neutron D2O-H2O solvent maps: pattern of primary and secondary hydration of trypsin.
Academic Article Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Academic Article Deciphering the role of the electrostatic interactions involving Gly70 in eglin C by total chemical protein synthesis.
Academic Article The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.
Academic Article Neutron structure of subtilisin BPN': effects of chemical environment on hydrogen-bonding geometries and the pattern of hydrogen-deuterium exchange in secondary structure elements.
Academic Article Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution.
Academic Article Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface.
Academic Article Structure of bistramide A-actin complex at a 1.35 angstroms resolution.
Academic Article Crystal structure and site 1 binding energetics of human placental lactogen.
Academic Article X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers.
Academic Article The 1.38 A crystal structure of DmsD protein from Salmonella typhimurium, a proofreading chaperone on the Tat pathway.
Academic Article X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Academic Article Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning.
Academic Article Exploring and designing protein function with restricted diversity.
Academic Article Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope.
Academic Article Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis.
Academic Article Tertiary structure is a principal determinant to protein deamidation.
Academic Article Total chemical synthesis and X-ray crystal structure of a protein diastereomer: [D-Gln 35]ubiquitin.
Academic Article Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Academic Article The X-ray structure of a growth hormone-prolactin receptor complex.
Academic Article A method of solvent structure analysis for proteins using D2O-H2O neutron difference maps.
Academic Article Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin.
Academic Article Protein dynamics investigated by neutron diffraction.
Academic Article Structure of the growth hormone-receptor complex and mechanism of receptor signaling.
Academic Article Crystal structures of subtilisin BPN' variants containing disulfide bonds and cavities: concerted structural rearrangements induced by mutagenesis.
Academic Article High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries.
Academic Article Effect of protein packing structure on side-chain methyl rotor conformations.
Academic Article The use of neutrons to show how proteins work.
Academic Article The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s).
Academic Article The crystallographically determined structures of atypical strained disulfides engineered into subtilisin.
Academic Article The three-dimensional structure of Bacillus amyloliquefaciens subtilisin at 1.8 A and an analysis of the structural consequences of peroxide inactivation.
Academic Article The application of neutron crystallography to the study of dynamic and and hydration properties of proteins.
Academic Article Generating conformation-specific synthetic antibodies to trap proteins in selected functional states.
Academic Article Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments.
Academic Article Nuclear pores. Architecture of the nuclear pore complex coat.
Academic Article Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.
Academic Article Cell biology. New tricks for an old dimer.
Academic Article Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
Academic Article Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin.
Academic Article Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation.
Academic Article Architecture of the fungal nuclear pore inner ring complex.
Academic Article Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs.
Academic Article Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
Academic Article Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.
Academic Article Structural basis for activation of voltage sensor domains in an ion channel TPC1.
Academic Article Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin.
Academic Article An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability.
Academic Article Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM.
Academic Article Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Academic Article Structure and mechanism of the ER-based glucosyltransferase ALG6.
Academic Article Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Academic Article Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
Academic Article Recognition of an a-helical hairpin in P22 large terminase by a synthetic antibody fragment.
Academic Article Engineered Ultra-High Affinity Synthetic Antibodies for SARS-CoV-2 Neutralization and Detection.
Academic Article Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody that Targets two Distinct Epitopes on av Integrins.
Academic Article Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
Academic Article A T cell redirection platform for co-targeting dual antigens on solid tumors.
Academic Article K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.
Academic Article Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Academic Article Structures of ABCB4 provide insight into phosphatidylcholine translocation.
Academic Article Structure of an AMPK complex in an inactive, ATP-bound state.
Academic Article Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Academic Article Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.
Academic Article Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.
Academic Article Structural basis of lipopolysaccharide maturation by the O-antigen ligase.
Academic Article Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.
Academic Article Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Academic Article Architecture of the cytoplasmic face of the nuclear pore.
Academic Article Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
Academic Article A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
Academic Article Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Academic Article Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
Academic Article Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
Academic Article Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
Concept beta-Arrestins
Concept beta-Arrestin 1
Concept Antineoplastic Agents, Immunological
Concept Cell Surface Display Techniques
Concept Single-Domain Antibodies
Concept Claudin-3
Academic Article Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Academic Article Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum.
Academic Article Conformation-specific synthetic antibodies discriminate multiple functional states of the ion channel CorA.
Academic Article Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA.
Academic Article Cryo-EM structures of a synthetic antibody against 22 kDa claudin-4 reveal its complex with Clostridium perfringens enterotoxin.
Academic Article Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.
Academic Article ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding.
Academic Article Structure of human drug transporters OATP1B1 and OATP1B3.
Academic Article Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme uptake.
Academic Article Structural and molecular basis of choline uptake into the brain by FLVCR2.
Academic Article Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Academic Article The Molecular Basis of Human ALKBH3 Mediated RNA N1 -methyladenosine (m1 A) Demethylation.
Academic Article Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding.
Academic Article Structural analysis and conformational dynamics of a holo-adhesion GPCR reveal interplay between extracellular and transmembrane domains.
Academic Article Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP.
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